مشخصات کلی Heart transplantation using allografts from older donors: multicenter study results

نویسنده کتاب (Author):

Roig, Eulàlia; Almenar, Luis; Crespo-Leiro, María Generosa; Segovia, Javier; Mirabet, Sònia; Delgado, Juan; Pérez-Villa, Félix; Lambert, José Luis; Blasco, M. Teresa; Muñiz, Javier

انتشارات (Publisher):

Elsevier 2014-11-14

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

roig-e-almenar-l-crespo-leiro-m-et-al-heart-transplantation-using-allografts-from-older-donors-multicenter-study-results-j-heart-lung-transplant-2015346790-6

موضوع (Subject):

Heart transplantation       Older donors       Cardiac allograft vasculopathy       View all subjects      

توضیحات خلاصه (Summary):

[Abstract] Background. The lengthy waiting time for heart transplantation is associated with high mortality. To increase the number of donors, new strategies have emerged, including the use of hearts from donors ≥50 years old. However, this practice remains controversial. The aim of this study was to evaluate outcomes of patients receiving heart transplants from older donors. Methods. We retrospectively analyzed 2,102 consecutive heart transplants in 8 Spanish hospitals from 1998 to 2010. Acute and overall mortality were compared in patients with grafts from donors ≥50 years old versus grafts from younger donors. Results. There were 1,758 (84%) transplanted grafts from donors < 50 years old (Group I) and 344 (16%) from donors ≥50 years old (Group II). Group I had more male donors than Group II (71% vs 57%, p = 0.0001). The incidence of cardiovascular risk factors was higher in older donors. There were no differences in acute mortality or acute rejection episodes between the 2 groups. Global mortality was higher in Group II (rate ratio, 1.40; 95% confidence interval, 1.18–1.67; p = 0.001) than in Group I. After adjusting for donor cause of death, donor smoking history, recipient age, induction therapy, and cyclosporine therapy, the differences lost significance. Group II had a higher incidence of coronary allograft vasculopathy at 5 years (rate ratio, 1.67; 95% confidence interval, 1.22–2.27; p = 0.001). Conclusions. There were no differences in acute and overall mortality after adjusting for confounding factors. However, there was a midterm increased risk of coronary allograft vasculopathy with the use of older donors. Careful selection of recipients and close monitoring of coronary allograft vasculopathy are warranted in these patients.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Roig, Eulàlia; Almenar, Luis; Crespo-Leiro, María Generosa; Segovia, Javier; Mirabet, Sònia; Delgado, Juan; Pérez-Villa, Félix; Lambert, José Luis; Blasco, M. Teresa; Muñiz, Javier

شناسه OCLC:979265388

Language Note:English

فهرست محتوا:http://hdl.handle.net/2183/17512

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