ژورنال اصلی BioMed Central Ltd.

download pdf Specific immunotherapy ameliorates ulcerative colitis, دانلود Specific immunotherapy ameliorates ulcerative colitis,Cai, Min; Zeng, Lu; Li, Lin-Jing; Mo, Li-Hua; Xie, Rui-Di; Feng, Bai-Sui; Zheng, Peng-Yuan; Liu, Zhi-Gang; Liu, Zhan-Ju; Yang, Ping-Chang, کتاب های Cai, Min; Zeng, Lu; Li, Lin-Jing; Mo, Li-Hua; Xie, Rui-Di; Feng, Bai-Sui; Zheng, Peng-Yuan; Liu, Zhi-Gang; Liu, Zhan-Ju; Yang, Ping-Chang,BioMed Central Ltd. 2016-08-05, لیست کتاب های BioMed Central Ltd. 2016-08-05,WorldCat, کتاب های WorldCat

گت بلاگز Internet Mapping networks of anti-HIV drug cocktails vs. AIDS epidemiology in the US counties / دانلود فایل

مشخصات کلی Mapping networks of anti-HIV drug cocktails vs. AIDS epidemiology in the US counties

نویسنده کتاب (Author):

Herrera-Ibatá, Diana María; Pazos, A.; Orbegozo-Medina, Ricardo Alfredo; González-Díaz, Humberto

انتشارات (Publisher):

Elsevier 2014-08-20

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

herrera-ibata-dm-pazos-a-orbegozo-medina-ra-gonzalez-diaz-h-mapping-networks-of-anti-hiv-drug-cocktails-vs-aids-epidemiology-in-the-us-counties-chemometrics-intel-lab-sys-2014

موضوع (Subject):

ChEMBL       AIDSVu       Anti-HIV drug cocktails       View all subjects      

توضیحات خلاصه (Summary):

[Abstract] The implementation of the highly active antiretroviral therapy (HAART) and the combination of anti-HIV drugs have resulted in longer survival and a better quality of life for the people infected with the virus. In this work, a method is proposed to map complex networks of AIDS prevalence in the US counties, incorporating information about the chemical structure, molecular target, organism, and results in preclinical protocols of assay for all drugs in the cocktail. Different machine learning methods were trained and validated to select the best model. The Shannon information invariants of molecular graphs for drugs, and social networks of income inequality were used as input. The nodes in molecular graphs represent atoms weighed by Pauling electronegativity values, and the links correspond to the chemical bonds. On the other hand, the nodes in the social network represent the US counties and have Gini coefficients as weights. We obtained the data about anti-HIV drugs from the ChEMBL database and the data about AIDS prevalence and Gini coefficient from the AIDSVu database of Emory University. Box–Jenkins operators were used to measure the shift with respect to average behavior of drugs from reference compounds assayed with/in a given protocol, target, or organism. To train/validate the model and predict the complex network, we needed to analyze 152,628 data points including values of AIDS prevalence in 2310 counties in the US vs. ChEMBL results for 21,582 unique drugs, 9 viral or human protein targets, 4856 protocols, and 10 possible experimental measures. The best model found was a linear discriminant analysis (LDA) with accuracy, specificity, and sensitivity above 0.80 in training and external validation series.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Herrera-Ibatá, Diana María; Pazos, A.; Orbegozo-Medina, Ricardo Alfredo; González-Díaz, Humberto

شناسه OCLC:979265421

Language Note:English

فهرست محتوا:0169-7439 http://hdl.handle.net/2183/17999

نویسنده : getblogs