ژورنال اصلی BioMed Central Ltd.

download pdf Specific immunotherapy ameliorates ulcerative colitis, دانلود Specific immunotherapy ameliorates ulcerative colitis,Cai, Min; Zeng, Lu; Li, Lin-Jing; Mo, Li-Hua; Xie, Rui-Di; Feng, Bai-Sui; Zheng, Peng-Yuan; Liu, Zhi-Gang; Liu, Zhan-Ju; Yang, Ping-Chang, کتاب های Cai, Min; Zeng, Lu; Li, Lin-Jing; Mo, Li-Hua; Xie, Rui-Di; Feng, Bai-Sui; Zheng, Peng-Yuan; Liu, Zhi-Gang; Liu, Zhan-Ju; Yang, Ping-Chang,BioMed Central Ltd. 2016-08-05, لیست کتاب های BioMed Central Ltd. 2016-08-05,WorldCat, کتاب های WorldCat

گت بلاگز Internet Microemulsions for colorectal cancer treatments: general considerations and formulation of methotrexate / دانلود فایل

مشخصات کلی Microemulsions for colorectal cancer treatments: general considerations and formulation of methotrexate

نویسنده کتاب (Author):

Flores, Sergio E.; Rial-Hermida, M.Isabel; Ramírez, Jorge C.; Pazos, A.; Concheiro, Ángel; Álvarez-Lorenzo, Carmen; Peralta, René D.

انتشارات (Publisher):

Bentham 2016-04-01

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

flores-se-rial-hermida-mi-ramirez-jc-et-al-microemulsions-for-colorectal-cancer-treatments-general-considerations-and-formulation-of-methotrexate-mini-rev-med-chem-2016166498-508

موضوع (Subject):

Antitumor therapy       Colorectal cancer       Essential oils       View all subjects      

توضیحات خلاصه (Summary):

[Abstract] Microemulsions combine the advantages of emulsions with those of nanocarriers, overcoming the stability problems of the former and providing facile scalable systems with compartments adequate for high drug loadings. Recently, microemulsions are gaining attention in the formulation of anticancer drugs not only for topical treatment, but also for systemic delivery as well as for the development of theranostic systems. The aim of this paper is two-fold. First, an updated review about general features, preparation, characterization and pharmaceutical applications, with a special focus on colorectal cancer, is provided. Second, a case study of formulation of methotrexate in microemulsions is presented. Various essential oils (menthol, trans-anethole, α-tocopherol) and surfactants (TPGS-l000, Maxemul 6112, Noigen RN-20) were investigated for the preparation of o/w microemulsions for the delivery of methotrexate, and the ability of methotrexate-loaded microemulsions to inhibit cancer cell growth was then evaluated. Disregarding the surfactants used, menthol and trans-anethole led to cytotoxic microemulsions, whereas α-tocopherol based-formulations induced cell proliferation. These findings highlight the role that the oily component may play in the efficacy and safety of the microemulsions.  Read more…

ژانر / فرم:info:eu-repo/semantics/article

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Flores, Sergio E.; Rial-Hermida, M.Isabel; Ramírez, Jorge C.; Pazos, A.; Concheiro, Ángel; Álvarez-Lorenzo, Carmen; Peralta, René D.

شناسه OCLC:979265301

Language Note:English

فهرست محتوا:http://hdl.handle.net/2183/17508

نویسنده : getblogs